ارتباط بين ريشه كني هليكوباكترپيلوري و بهبود باليني با چهار رژيم دارويي مختلف در بيماران با ديس پپسي مزمن

THE CORRELATION BETWEEN ERADICATION OF HELICOBACTER PYLORI AND IMPROVEMENT SYMPTOMS BY FOUR DIFFERENT REGIMES IN PATIENTS WITH CHRONIC DYSPEPSIA

Background & Aims: Chronic dyspepsia is associated with Helicobacter pylori infection and motility disorder. Whether curing the infection actually improves the symptoms or no, remains highly controversial. In this study, we compared four regimes for eradication of H. pylori and its results on improvement of gastrointestinal symptom. Materials & Methods: This was a clinical trial which was performed on 160 volunteers from May 2007 to May 2008. Sixty five of them were excluded from our study. Using GIS score, each patient was given a score. In patients with positive Rapid Urease Test, we started the H. Pylori treatment by four regimes (triple therapy for 7 or 10 days, quadruple therapy for 1 or 3 days). The success of the treatment was confirmed by UBT test. In each group the response to treatment was recorded. Resultsʹ. Among 95 cases in this study, 10.5 % of the patients received quadruple therapy for one day, 22.1% for 3 days, 42.1% received triple therapy for 7 days, and 25.3% for 10 days. The eradication of H. Pylori was confirmed in 64.3% of the cases by UBT (after 6 weeks). The rate of eradication in 7 and 10 day regimes were 70% and 79.2% and in one and three days regimes were 30% and 61.9% respectively (P=0.041%). The mean GIS recovery score before and after treatment was significant (p=0.03). Conclusion: Although GIS score improvement didnʹt differ significantly in different therapeutic regimes, the best symptom improvement was recorded for patients with successful eradication. Keywordsʹ. Helicobacter Pylori, Dyspepsia, Triple therapy, Quadruple therapy Address: Internal Medicine Department, Ghaem Medical Center Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Tel: 0511 -8400000