بررسي اثر هپاتيت B و C بر آنمي در بيماران همودياليزي

Effect of hepatitis C and B infections on anemia in hemodialysis patients

Background: Hepatitis C (HCV) and B (HBV) infections are commonly seen in dialysis patients, but them long-term deleterious effects in these patients are unknown. We evaluated the effect of HCV and HBV infections on anemia in our hemodialysis population. M. Ghadir (MD)1* M. Mousavi Movahhed (MD)2 A. komeili movahhed (MD)3 T. komeili movahhed (MSc)4 A. Heidari (PhD)5 1- Assistant Professor of Gastroentrology, (QUMS) 2- Assistant Professor of Nephrology, (QUMS) 3- General Practitioner , Researcher 4- Director of Laboratory of Biochemistry, Department of Biochemistry and Genetics , School of medicine (QUMS) 5- Asistant Professor of Social Medicine, (QUMS) Methods: A total of 90 chronic hemodialysis patients with anemia at kamkar and Hazrat Valiasr hemodialysis centers were included for the period 3 months, in 2008. Data classified according to the hepatitis-free, chronic hepatitis B and C groups. Nineteen HCV- positive and eleven HBV-positive patients were included for comparison analysis with 60 control patients. Erythropoietin was administered for 3 month.They were followed for 3 months and their hemoglobin and hematocrit were measured before administration of erythropoietin and the end of third month. For statistical analysis, T-test was employed Results: The mean rise of hemoglobin and hematocrit in hepatitis- free, HCV and HBV groups were 1.50 ±1.45 g/dL and 3.88% ± 5.01%, 2.56 ± 1.40 g/dL and 7.56%±3.75%, 1.86±1.17 g/dL and 5.73% ± 4.11%,respectively. The mean rise of hemoglobin and hematocrit in HCV group was significantly higher than hepatitis-free group and t test showed a significant statistical correlation. However the mean rise of hemoglobin and hematocrit in HBV group was higher than hepatitis-free group but t test didnʹt show a significant statistical correlation. Conclusion: We found that hepatitis C virus infection was associated with significant elevation in mean of hemoglobin and hematocrit than hepatitis-free group. Correspondentʹs Address: Qom university of medical sciences ,Qom Tele:0251-2921221 Fax:0251-2909288 Key words: Hepatitis C, Hepatitis B, hemodialysis, anemia