توليد و ارزيابي راديونوكليد 186Reبا استفاده از راكتور تحقيقاتي تهران براي مقاصد درماني

Production and Evaluation of 186Re Radionuclide in the Tehran Research Reactor for Therapeutic Applications

In this work, the production of 186Re by 185Re (n,y) 186Re reaction in the Tehran Research Reactor (T.R.R) is investigated. The activity of 186Re was measured after a cooling time of 4 days, using a liquid beta scintillation system and a dose calibrator. Also, activity of the samples were calculated using fluxes determined by Monte Carlo simulation of the reactor core. The calculated and measured values for the activity of irradiated samples are comparable in the range of ±18% and the irradiation correction factors are 1.135 and 0.820 for natural rhenium (thermal neutron flux of 6.5><1013 cm"2 s"1) and rhenium samples with high the isotope abundance of 185Re (thermal neutron flux of 1.18><1013 cm"2 s"1), respectively. The results have shown that t86Re samples (in the form of perrhenate) can be achieved with 96.5% radiochemical purity and 99% radionuclidic purity. The products with the high specific activity of about 300mCi/mg for therapeutical aplications can be achieved in T.R.R. using rhenium sample target with a high abundance from rhenium-185 target; and for the medium with the mean specific activity, natural rhenium can be used.