مقايسه حداقل غلظت مهاري عصاره گياه مورد و نيستاتين بر روي سويه هاي كلينيكي و استاندارد candida albicans در شرايط آزمايشگاهي

In vitro Comparison of Minimum Inhibitory Concentration of Myrtus Communis L. Extract and Nystatin on clinical Isolates and standard strains of Candida albicans

In this survey in vitro inhibitory effects of Myrtus Communis extract and nystatin on clinical Isolates of Candida albicans from Vulvovaginal Candidiasis and Standard Strains of C.albicans were studied. The plant extracSt was obtained from Barij essence Co. The type strains of c.albicans were prepared from ATCC90028 collections. 45 clinical Isolates of c. albicans that were confirmed by microbiological methods used in the tests. Inhibitory effects of the Extract analyzed by serial dilution broth technique after determination of antimicrobial bioactivity. Based on the data analysis the best minimum inhibitory concentration (MIC) of M.Communis L. extract on clinical Isolates and type strain of c.albicans were 25 mg/ml and 2.5 mg/ml, respectively. Also the best MIC of Nystatin on clinical Isolates and type strain of C.albicans were 36 mg/ml the obtained Results showed that Myrtle extract has Inhibitory effect on clinical Isolates and type strain of C.albicans in lower concentrations than Nystatin drug . The present study suggest consideration of the plants extract with the highest antimicrobial activity and forms the basis for further Investigations to isolate active components , elucidated the structures and evaluate them against wider range of microbial Strains with the goal to find new the therapeutic principles. Substitution of commonly used Antifungal and Inhibiting chemicals by natural extracts such as Myrtle is recommended.