بررسى تاثير عصاره آبى – الكلى گياه يونجه بر ترميم و بازسازى اپى تليوم پوست لاله گوش خرگوش

Effects of Medicago sativa hydroalchol extract on wound healing of epithelium in New Zealand rabbitʹs ear

For many years, herbal medicines have been used as healing medicines in different societies. At the moment, in spite of advancement of the synthetic medicines, the herbal medicines are still used and this is due to the fact the natural combinations have less side effect compared to the synthetic medicines. In this study, the effects of Medicago sativa hydroalchol extract on wound healing of epithelium in rabbitsʹ ear was investigated. In this research work, 6 New Zealand male rabbits, each with the weight of about 1.5 kg, were selected. We used standard metal earpunch that marked for this purpose. We created well-circum scribed circular surgical wounds of 4 mm in diameter. In each rabbit, one pinna day-o-day treated with Medicago sativa hydroalchol extract and the other one was as control. Each holes were studied every other day and measured for both test and control groups to compare the speed of wound healing. The macroscopic investigations based on statistical analysis show that the speed of healing in the treated wounds with the Medicago sativa hydroalchol extract was significantly greater than the control group. The histological investigations based on statistical analysis show that epiderm thickness , number and lenght dermal papillae in the test group was significantly increased than control group. It can be concluded that the Medicago sativa hydroalchol extract probably has a positive effects on healing of wounds.