ارتباط پلي مورفيسم 11377C

Association of polymorphism -11377C>G of Adiponectin gene with obesity

Adiponectin plays an important role in the genetic predisposition to obesity, and insulin resistance. Adiponectin gene has numerous polymorphisms. There is a relationship between polymorphisms of this gene and Adiponectin level as well as obesity. The study was investigated frequency and the relationship between one of the effective polymorphism(-11377C>G) on the Adiponectin level with obesity in women. One hundred eighty subjects participated in this study who were randomly. Fasting Blood Sugar (FBS), HDL-C, LDL-C, triglyceride, total cholesterol, adiponectin levels were determined. Genotyping of the polymorphism of the Adiponectin gene (- 113770G )was determined by polymerase chain reaction (PCR)-based restriction fragment length polymorphism KFLP(Hhal). Data were compared statistically by Kruskal-Wallis test . All data were analyzed using SPSS, version 15. The frequencies of G and C alleles were also 0.203 and 0.797 respectively appears to be consistence with Hardy- Weinberg equilibrium. The women who carried this polymorphism in promoter had lower BMI and LDL-C and more HDL-C and adiponectin of other groups, however, these associations were not significant. The results is not showed significant associations between this polymorphism and obesity, it seems more investigations in other polymorphisms in this gene and increasing samples would be useful to elucidation more accurately of this association.