تاثير تركيب سه داروي ديازپام، كتامين و پتيدين بر فراموشي واپس نگر پس از بيهوشي عمومي

ffect of diazepam, ketamine and pethidine on retrograde amnesia after general anesthesia

Background; Information about retrograde amnesia in the perioperative period is scarce. The amnesia produced by anesthesia is advantageous for unpleasant events like awareness under anesthesia or an uncomfortable feeling in the recovery room. It may be difficult to clear the memory that has been stored in the brain. The aim of this study is to induce retrograde amnesia with ketamine, diazepam, and pethidine. Materials and methods: 150 patients aged 18 to 35 years (ASA I) undergoing surgery and general anesthesia were included in this study. In the post¬anesthesia care unit (PACU), each patient underwent identical auditory* visual, and sensory stimulus. Then the drugs were administered. There were 50 patients in each of three groups; the first group ketamine 0.3 mg/kg in addition to diazepam 0.1 mg/kg and pethidine 0.3 mg/kg; the second group ketamine 0.5 mg/kg in addition to diazepam and pethidine; and the control group. After the patients became awake again and before being discharged from PACU and alsoiO hours after discharge, the memory of the patients was evaluated. Results: All (100%) patients in control and low dose ketamine groups were able to remember the day events. Among patients who received 0.5 mg/kg of ketamine two were unable to remember all the stimulus before drug administration (p=0.13); and besides three were unable to remember the visual stimulus only. The rest of 45 patients in this higher dose ketamine group remembered all the events and the stimulus.