بررسي تاثير ويتامين C تزريقي بر شاخص التهابي CRP در بيماران هموياليزي

The Effect of Intravenous Vitamin C on the Level of CRP in Hemodialysis Patients

Abstract Background and purpose: Inflammation is a common feature in hemodialysis patients which is characterized by increasing in inflammatory biomarkers such as C - reactive protein (CRP). One of the main predictors of complications and mortality in Dialysis Patients is increased level of CRP. The aim of this study was to determine the effect of intravenous vitamin C on the level of CRP in hemodialysis patients. Materials and methods: In this double blind randomized clinical trial, 60 patients were allocated in two groups (intervention and control). At the end of each hemodialysis session, the intervention group received vitamin C (500mg/5cc) intravenously, three times a week for 8 weeks and the control group received normal saline in a same way. The level of CRP was compared in both groups before and after the intervention. Data were analyzed by Independent T test, Paired T test and Chi-square tests. Results: According to this study, plasma level of CRP was significantly decreased in the intervention group (p<0.05) but in the control group there was no significant difference statistically. Conclusion: The use of intravenous vitamin C supplement reduces CRP level in hemodialysis patients.