پديد آورندگان :
Ranjbar-Heidari، Azadeh نويسنده Department of Developmental Zoology, science Faculty, Mashhad branch, Islamic Azad University, Mashhad, Iran Ranjbar-Heidari, Azadeh , Khaiatzadeh، Jina نويسنده Department of Developmental Zoology, science Faculty, Mashhad branch, Islamic Azad University, Mashhad, Iran Khaiatzadeh, Jina , Mahdavi-Shahri، Naser نويسنده Department of Biology, Islamic Azad University, Mashhad branch, Mashhad, Iran Mahdavi-Shahri, Naser , Tehranipoor، Maryam نويسنده Department of Animal Physiology, Mashhad branch, Islamic Azad University, Mashhad, Iran Tehranipoor, Maryam
كليدواژه :
diabetes , Lesion Healing , Prosopis Farcta , Rat
چكيده لاتين :
Background: Wound healing in diabetes is one of the challenges in the medical science. Accordingly, new quick wound-healing compounds are welcomed. It is likely that Prosopis farcta - indigenous to southeastern Iran – accelerates regenerating process for its anti-inflammatory, antimicrobial and antidiabetic effects. This study is aimed at examining the local effect of the fruit dusk powder and root extract of Prosopis farcta on diabetic healing.
Materials and Methods: Twenty-four male Wistar rats were randomly divided into 4 groups of intact, diabetic control, Experimental group 1(diabetic treated with fruit powder) and Experimental group 2 (diabetic treated with root extract). Diabetic groups were injected streptozotocin (STZ). Then, three holes (4 mm diameter) were made on both dorsal sides of the rats in all groups. Experimental groups were treated by fruit dusk powder and the plant root aquatic extract and the control groups were treated by normal saline. The area of the holes was continuously measured till they were completely closed.
Results: In the treatment groups using fruit dusk powder and plant root aquatic extract, the hole area had significantly decreased (p < 0.05).
Conclusion: It Seems that local administration of Prosopis farcta fruit dusk powder and root aquatic extract probably accelerates healing in diabetic rats. Regarding the antidiabetic, anti-inflammatory and healing effects of this plant, we are hopeful that Prosopis farcta plant finds an appropriate status in traditional medicine and pharmacology.
