پديد آورندگان :
Dehghanifard، Ali نويسنده Department of Laboratory Sciences, Faculty of Medicine, Islamic Azad University, Tehran Medical Branch, Tehran, Iran Dehghanifard, Ali , Mortazavi، Yousef نويسنده , , Saki، Najmaldin نويسنده Department of Hematology and Blood Banking School of Medical Sciences, Tarbiat Modares University, Tehran, Iran , , Farshdusti-Hagh، Majid نويسنده Department of Hematology, Division of Laboratory Hematology and Blood Banking, Tabriz University of Medical Sciences, Tabriz, Iran Farshdusti-Hagh, Majid
كليدواژه :
Favism , Glucose-6-phosphate , hemolytic anemia , Mediterranean Variant , Dehydrogenase
چكيده لاتين :
Background: G6PD deficiency is the most common hereditary enzyme deficiency that affected more than 400 million people worldwide. This enzyme deficiency is caused by a spectrum of mutations in the gene encoding G6PD on chromosome X. Epidemiologically; G6PD deficiency has been specially considered in Middle East countries including Iran, Oman and Saudi Arabia.
Materials and Methods: This study has reviewed more than 70 papers related to the epidemiological significance and various diagnostic strategies of G6PD deficiency from 1956 to 2010.
Results: The results showed a higher prevalence of Mediterranean variant followed by Chatham and Cosenza compared to other variants in Iran.
Conclusion: Accurate identification of G6PD deficiency variants in areas with high prevalence of this disease will help to screen patients and their families with risk level when faced with oxidant agents.
