پديد آورندگان :
Fallah-Mohammadi، Ziya نويسنده Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran Fallah-Mohammadi, Ziya , Ebrahimzadeh، Mojtaba نويسنده Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran Ebrahimzadeh, Mojtaba , Hajizadeh-Moghaddam، Akbar نويسنده Departmentof Animal Physiology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran Hajizadeh-Moghaddam, Akbar
چكيده لاتين :
Background: Amyloid Beta (1-42) is derived from amyloid precursor protein and plays a critical role in AD pathogenesis. The purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain Amyloid beta (1-42) in the diabetic rats induced with alloxan.
Materials and Methods: 28 male rats weight 185±1 were assigned randomly to 4 groups (N=7): normal control (C), training (T), control-diabetic (CD) and diabetic-training (DT). Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) intraperitoneal.
Results: 6 weeks of voluntary wheel running decreased the cortex AB1-42 in T and DT groups. AB1-42 levels significantly decreased in the T and DT in compare with C and CD (p < 0.001), respectively. Also AB1-42 levels significantly increased in the CD in compare with C (p < 0.001).
Conclusion: voluntary exercise had positive effects on decreasing of AB1-42 levels during 6 weeks. Therefore it can be recommended as therapeutic strategy for diabetes.
