پديد آورندگان :
Johari، Habiballah نويسنده Department of Physiology, Darab Branch, Islamic Azad University, Darab, Iran Johari, Habiballah , Delirnasab، Fatemeh نويسنده Department of Physiology, Kazeron Branch, Islamic Azad University, Kazeron, Iran Delirnasab, Fatemeh , Sharifi، Esfandiar نويسنده Biology Department, Islamic Azad University Kazeroun Branch, Kazeroun, Iran , , Hemayat-Khah، Vahid نويسنده Department of Physiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran Hemayat-Khah, Vahid , Pourdanesh، Mohammadali نويسنده Department of Histology, Jahrom Branch, Islamic Azad University, Jahrom, Iran Pourdanesh, Mohammadali , Kargar، Hosein نويسنده Department of Physiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran Kargar, Hosein , Nikpour، Maryam نويسنده Student Research Committe, International Branch, Shiraz University of Medical Science, Shiraz, Iran Nikpour, Maryam , Yazdani، Mohammad نويسنده Department of Agriculture, Firouz-Abad Branch, Islamic Azad University, Firouz Abad, Iran Yazdani, Mohammad
كليدواژه :
kidney , poisoning , rats , Zingiber officinale (ginger) , Lead
چكيده لاتين :
Background: In the present research, the effects of hydro-alcoholic extract of Zingiber officinale (ginger) on treating lead-poisoned kidney of neonatal rats was studied.
Materials and Methods: This research was conducted as a laboratory work. The neonatal rats were divided into 7 groups of 10 samples. The first control group received no treatment. The second control group received 0.1 mg of distilled water. As an experimental group, the one received an amount of 0.6 g/l lead. The fourth group received only 2 g/kg body weight of hydro-alcoholic extract of ginger. Groups 5 to 7 each initially received 0.6 g/l lead and then amounts of 0.5, 1 and 2 g/kg hydro-alcoholic extract of ginger. The injections were administered via oral gavage during 10 consecutive days.
Results: According to the obtained results, the body and kidney weights showed a significant reduction in experimental groups that had received amounts of 1 and 2 g/kg in comparison with the group that had received lead. The kidney weight of the group that had received only extract showed no significant difference in comparison with the control group. As for the body weights, however, it showed a significant increase. Moreover, the body and kidney weights of the lead-injected group showed a significant increase in comparison with the control group.
Conclusion: Lead can cause damage to kidney tissues. Due to its antioxidant and protective effect, ginger can be a medication to nephrotoxicity of lead and prevent kidney tissues from destruction.
