پديد آورندگان :
Keyshams، Negar نويسنده Department of Physiology, Faculty of Sciences, Shahid Chamran University, Ahvaz, Iran Keyshams, Negar , Fatemi، S. Reza نويسنده Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Fatemi, S. Reza , Najafzadehvarzi، Hossein نويسنده Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran Najafzadehvarzi, Hossein , Ashrafi، Ali نويسنده Department of Materials, Faculty of Engineering, Shahid Chamran University, Ahvaz, Iran Ashrafi, Ali
كليدواژه :
Ammonium mono vanadate , diabetes , nanoparticle , Rat
چكيده لاتين :
Background: Vanadium compounds have antidiabetic, but there is no study about the antidiabetic effects of ammonium monovanadate nono-particles. In this study, antidiabetic effect of ammonium monovanadate was compared with its nonoparticles.
Materials and Methods: In this experimental and animal modeling study, 42 male Sprague Dawley rats were divided in 6 groups (each group 7 rats). Diabetes was induced by IP injection of 60 mg/kg streptozicin to five groups. One normal group and one diabetic group were kept without treatment as control groups. Other diabetic rats were treated with nonovanadate 25 mg/kg (NV25), ordinary vanadate 25 mg/kg (V25), nonovanadate 15 mg/kg (NV15) and water ordinary vanadate 25 mg/kg (WV25) groups for 10 days by gavage. Heparinized blood was collected at days 11 and 21 and centrifuged to separate plasma. Glycosylated hemoglobin, insulin, triglyceride (TG), total cholesterol (TC), HDL-c and LDL-c were measured at both time and compared between groups.
Results: All treatment except in V25 decreased glycemia, but insulin increased only in NV25 group (p < 0.05). All treatment decreased TG, TC and LDL-c significantly (p < 0.001).
Conclusion: Ammonium mono vanadate nonoparticle has better effects than ordinary ammonium mono vanadate on some biochemical factors in experimental diabetes.
