برآورد خطر ابتلا به سرطان هاي دستگاه گوارش فوقاني در افراد داراي سابقه فاميلي سرطان

Risk Estimation of Upper Gastrointestinal Cancers in People with Family History of Cancer

Introduction: Upper gastrointestinal cancers are one of the major causes of cancer related death in the world. Family history is a serious risk factor for upper gastrointestinal cancers, but there is little information about this, in Iran. Therefore, this study aimed at investigating the impact of familial history of cancer on upper gastrointestinal cancers development. Methods: In this case-control study, 1010 cases of upper gastrointestinal cancer and 1010 healthy controls were recruited. The family history was extracted from a standard history form completed by a health care provider. Adjusted odds ratio estimates for the association between family history and upper gastrointestinal cancers risk and corresponding 95% confidence intervals were obtained. Results: A positive family history was reported by 22% and 23.5% among cases and controls, respectively (P > 0.05). An immediate family history of esophageal and gastric cancer was significantly associated with upper gastrointestinal cancers development, with an adjusted OR of 4.7. Conclusion: According to our findings family history of cancer increases the risk of upper gastrointestinal cancers. Due to this fact, it is recommended that relatives of patients with upper gastrointestinal cancers be considered as a priority group for screening programs.