رابطه‌ي كمرين و شاخص‌هاي سندرم متابوليك در مادران باردار با ديابت بارداري و مادران باردار سالم

The Relation of Serum Chemerin Levels with Parameters of Metabolic Syndrome between Pregnant Women with Gestational Diabetes and Normal Pregnant Women

مقدمه: كمرين آديپوكاين جديدي است كه نقش آن در تاثير انسولين و تمايز بافت چربي بررسي شده بود. در پژوهش حاضر كمرين در سرم مادران باردار با ديابت بارداري و سالم در سنين بارداري يكسان، از نظر تاثير بر روند متابوليكي آن‌ها و بروز ديابت بارداري مقايسه گرديد. مواد و روش‌ها: نمونه‌هاي سرمي 100 مادر باردار با ديابت بارداري و 100 مادر باردار سالم با آگاهي و اظهار رضايت كتبي جمع‌آوري گرديد. سطح كمرين و عوامل موثر بيوشيمي و متابوليكي قند ـ چربي اندازه‌گيري شدند، لپتين خون بند ناف 50 نوزاد مادر ديابتي با ديابت بارداري و 50 نوزاد مادر باردار سالم نيز تعيين شد. يافته‌ها: ميانگين كمرين سرم مادران با ديابت بارداري (06/46±152)، بيشتر (001/0P < ) از مادران باردار سالم (07/43±07/128) به دست آمد، كه رابطه‌ي آن با فاكتورهاي متابوليكي: نمايه‌ي توده‌ي بدن (05/0P < )، مقاومت به انسولين (001/0P < )، انسولين ناشتا (001/0 < P) و قند ناشتا (01/0P < ) اندازه‌گيري شدند. نتيجه‌گيري: سطح كمرين مادران باردار با ديابت بارداري به طور معني‌داري بالاتر از مادران سالم بود. كمرين سرم جداگانه با شاخص‌هاي مقاومت با انسولين و توده‌ي بدني هم رابطه‌ي مثبت نشان داد. بين كمرين، لپتين، فاكتورهاي بيوشيميايي و متابوليكي نوزادان مادران با ديابت بارداري و سالم همبستگي مشاهده نشد، كه نقش آن در بروز سندرم متابوليك، چاقي و عوارض ديابت مي‌باشد.

Introduction: Chemerin as a new adipokine has recently been studied for its crucial role in adipocyte differentiation and insulin signaling. In this study, chemerin levels were determined in the serum of pregnant women of the same gestational age with gestational diabetes mellitus (GDM) and compared with those of healthy pregnant women for their impact on the metabolic process and incidence of gestational diabetics. Materials and Methods: After obtaining a written consent of each individual, totally 200 serum samples were collected from the healthy and gestationally diabetic pregnant women groups. In addition to chemerin, other effective biochemical and metabolic factors of carbohydrate and lipid were determined. Leptin content of cord blood was measured in 100 infants from healthy (50) and gestational diabetes (50) groups. Results: Mean serum chemerin levels of pregnant women with gestational diabetes (152.4±46.5 µg/dl) were significantly higher (p < 0.001) in comparision with those of non-diabetic pregnant women (128.7±43.7 µg/dl). Serum chemerin levels were significantly associated with metabolic syndrome-related parameters, including body mass index (BMI) (P < 0.05), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (P < 0.001), fasting insulin (P < 0.001) and fasting blood (p < 0.01) was conducted. Serum chemerin was not significantly correlated with cord blood leptin. Conclusion: Serum chemerin levels were higher in pregnant women with gestational diabetes than their non-diabetic pregnant counterparts. Serum chemerin was also independently associated with markers of insulin resistance, and body mass index. Leptin, biochemical and metabolic parameters of mother’s infants were not correlated between the two groups.