پديد آورندگان :
Rezaei، Ali نويسنده Department of Clinical Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran Rezaei, Ali , Pashazadeh، Mehrdad نويسنده Department of Biology, Young Researchers and Elite Club, Ahar Branch, Islamic Azad University, Ahar, Iran Pashazadeh, Mehrdad , Pashazadeh، Mahdi نويسنده General Physician, Tabriz Branch, Islamic Azad University, Tabriz, Iran Pashazadeh, Mahdi , Moghadam، Sajad نويسنده Student of Biology, Ahar Branch, Islamic Azad University, Ahar, Iran Moghadam, Sajad
كليدواژه :
Hypericum , Rat , Ketamine , Nardostachys , Sedative
چكيده لاتين :
Background: Nardostachys and hypericum due to the effects of sedation, anticonvulsant, analgesic and anti-depressants has especial place in traditional medicine. Principal component and the alkaloid extract of valerian and isovalerate, valeric acid and the extract of hypericum is hypersin and hyperforin.
Materials and Methods: We conducted this study, valerian rhizome by chloroform: methanol (70:30) was extracted in order to obtain total extract produced the N-hexane and studied chemically have been took by Gc-Ms. Hydro-alcoholic extract of aerial valerian tea was prepared for study. In order to study the comparative effects of soothing extracts of valerian and hypericum in different groups of female rat extract of valerian with doses of 100 mg/kg, 200 mg/kg, 400 mg/kg, and extracts of hypericum with a dose of 250 mg/kg, 500 mg/kg and DMSO (control) with the same volume of 15 minutes prior to the assessment of sedative and sleep (sleep duration induced with ketamine dose and 40 mg/kg were injected intraperitoneally).
Results: The results indicate a significant increase in sleep time induced by ketamine in the treatment groups with high and low doses of valerian extracts and the hypericum is significant at the 0.01 level.
Conclusion: The results show that the extract of valerian in the dose of 200 mg/kg in compress of dose of hypericum 500 mg/kg contains the significant anesthetic effects.
