ميزان ناقل بودن بيماران سرپايي داراي التهاب روده به كلستريديوم ديفيسيل

Clostridium difficile Carriage Rate in Outpatients with Inflammatory Bowel Diseases

Abstract Background and objective: Closteridium difficile is a gram positive, anaerobic and spore-forming bacillus. Inflammatory bowel disease or IBD includes Crohnʹs disease and ulcerative colitis. Inflammation of the intestinal mucosa in these patients can be as a risk factor for colonization of Clostridium difficile. The purpose of this study was to analysis of Clostridium difficile carriage in the IBD outpatients. Materials and methods: Stool specimens were obtained from 50 outpatients with IBD. Stools were cultured on selective media under anaerobic conditions. Filtered extract of bacteria was exposed to HeLa cell culture for analysis of toxin production after identification of Clostridium difficile isolates. Results: The results showed that 3 IBD patients (6%) had stool cultures positive for Clostridium difficile. Stool cultures were negative in all patients with Crohnʹs disease. All 3 patients had ulcerative colitis. Only one isolate was positive for toxin production. Conclusion: The ulcerated colitis than Crohnʹs patients had higher carriage. In general IBD outpatients carriage rates for Clostridium difficile was low.