تاثير تمرين مقاومتي با بار فزاينده بر غلظت سرمي A-FABP و آپوليپوپروتيين A-I موش هاي صحرايي نر

Effect of progressive resistance training on serum A-FABP and Apolipoprotein A-I concentration in male rats

هدف از انجام پژوهش حاضر بررسي تاثير تمرين مقاومتي با بار فزاينده بر سطوح سرمي A-FABP و apoA-I بود. 16 سر موش صحرايي نر از نژاد ويستار (12 تا 14 هفته اي) به طور تصادفي به گروه هاي كنترل (8n=) و تمرين (8n=) تقسيم شدند. تمرين مقاومتي شامل بالا رفتن از نردبان (8 تكرار در روز، 3 روز در هفته، براي 4 هفته) با وزنه هاي آويزان شده به دم حيوان به ترتيب با وزنه هايي معادل با 50، 75 ،90 و 100 درصد ظرفيت حمل بيشينه ي جلسه ي قبل و افزايش 30 گرمي در تكرارهاي بعدي بود. غلظت ناشتاي A-FABP و apoA-I سرم همراه با پروفايل ليپيدي سرم و كبد اندازه گيري شد. پس از 4 هفته تمرين مقاومتي سطوح سرمي A-FABP و apoA-I گروه تمريني در مقايسه با گروه كنترل به طور معني داري بالاتر بود (به ترتيب؛ 026/0 = P و 028/0 = P). تفاوت معني داري در پروفايل ليپيدي سرم و كبد گروه ها مشاهده نشد (05/ 0 < P). اين نتايج بيانگر آن است كه تمرين مقاومتي با شدت مناسب ممكن است راه كار مداخله اي موثري براي افزايش سطوح سرمي A-FABP و apoA-I باشد.

Adipocyte fatty acid-binding protein (A-FABP), a member of FABPs family, plays an essential regulatory role in energy metabolism and inflammation, as well as apolipoprotein A-1 (apoA-I) is the major HDL-associated apolipoprotein. The purpose of this study was to investigate the effect of resistance training with progressive overload on serum A-FABP and apoA-I levels. Sixteen male Wister rats (12-14 weeks’ old) were randomly divided into control (n=8) and training (n=8) groups. The resistance training consisted of climbing (8 repetitions/day, 3 days/week, for 4 weeks) a ladder carrying a load suspended from the tail, with weights respectively equivalent to 50%, 75%, 90%, and 100% of their previous maximal carrying capacity and 30g increments for each subsequent climb. Fasting serum levels of A-FABP and apoA-I concentrations and lipid profile levels in serum and liver were measured. After four weeks resistance training serum A-FABP and apoA-I levels in training group were significantly higher than control group (respectively, P= 0.026 & P= 0.028). We did not find any significant difference in serum and liver lipid profile between groups (P > 0.05). These results indicated that resistance training with suitable intensity could be an effective strategy to increase serum A-FABP and apoA-I levels.