The Effect of Nitric Oxide with Minimal Stimulation on Patients with Polycystic Ovarian Syndrome

Objectives: Infertility is one of the most prevalent problems among young couples especially in women with Polycystic Ovary Syndrome. In women, PCO is associated with lack of ovulation, abdominal obesity and insulin resistance. The aim of this study is to investigate the effect of nitric oxide with minimal stimulation in the treatment of infertility in women with PCOS. Materials and Methods: In a randomized single blind clinical trial (RCT), 120 women who had polycystic ovarian syndrome (PCOS), were with PCOS who were eligible to be studied were divided into two groups; study group and a control group (60 patients in each group) and the effects of Nitric Oxide with minimal stimulation on the treatment of infertility were investigated in the patients who were being treated with IUI. Results: The mean age of the patients, who were 21 to 35 years old, was 28.3±4.2 years. In the study group, 43 cases (71.7%) and in the control group, 52 cases (86.7%) had ovulation. The difference between these two groups was statistically significant (p=0.03). The successful pregnancy rate was 10 cases (16.6%) in the study group and 8cases in the control group (13.3%), however this difference was not statistically significant (p=0.18). The difference between the two groups regarding mature follicles was not significant either (p=0.27), but the difference regarding the endometrial thickness on the gonadotropin administration day was statistically significant (p=0.02). Conclusion: According to the results and since there was not a significant difference between the two groups regarding the pregnancy rate, it can be concluded that employing nitric oxide tablets in addition to the common treatment, does not affect pregnancy rate in women with PCOS.