پديد آورندگان :
Sharifzadeh ، M نويسنده 1- Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Sharifzadeh, M , Ebadi ، N نويسنده 2- Department of Traditional Pharmacy, Faculty of Traditional Medicine andPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran Ebadi , N , Manayi ، A نويسنده 4- Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Manayi , A , Kamalinejad ، M نويسنده 5- Department of Pharmacognosy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Kamalinejad , M , Rezaeizadeh ، H نويسنده Student Scientific Research Center, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Iran Rezaeizadeh, H , Mirabzadeh ، M نويسنده 2- Department of Traditional Pharmacy, Faculty of Traditional Medicine andPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran Mirabzadeh , M , Bonakdar Yazdi ، B نويسنده 1- Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Bonakdar Yazdi , B , Khanavi ، M نويسنده 2- Department of Traditional Pharmacy, Faculty of Traditional Medicine andPersian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran Khanavi , M
كليدواژه :
Anti-inflammatory , Paw edema , Rubia tinctorum , Rubiaceae , Carrageenan
چكيده لاتين :
Background: Inflammation is a dynamic process that is elicited in response to various harmful stimulantsthat may threaten the well-being of the host. Herbs have been traditionally used as anti-inflammatory agents since very early times. Rubia tinctorum L. is one of these herbs that havebeen used for treating inflammatory diseases in Iranian traditional medicine.
Objective: This study aims at considering anti-inflammatory effects of R. tinctorum and comparing its extracts in this property.
Methods: The root of Rubia tinctorum (Rubiaceae) was collected from Yazd province, in the center of Iran. The root extracts of plant were studied for their anti-inflammatory activity by using carrageenan-induced hind paw edema in Wistarmale rats. Indomethacin and normal saline were used as positive and negative controls, respectively. Different concentrations of aqueous, ethanolic, and 50% aq. ethanolic extracts (600, 800, 1000 mg/kg) were given orally before carrageenan injection. The paw thickness was measured at 1, 3 and 5 hours after injection.
Results: Both, aqueous and 50% eq. ethanolic extracts reduced paw edema at 600 and 800 mg/kg concentrations. Moreover, ethanolic extract showed significant effect only in1sthour after carrageenan injection.
Conclusion: The results indicated that the aqueous extract were exhibited higher anti-inflammatory effect compared with other extracts. Accordingly, the potent anti-inflammatory effect of the root extracts is attributed to the polar compounds which are extracted in the water.
