تاثير امگا 3 بر اختلالات وازوموتور در زنان يايسه

Effect of omega3 on vasomotor disorders in menopausal women

چكيده زمينه و هدف: اختلالات وازوموتور يكي از رنج آورترين علايم دوران يايسگي است و كيفيت زندگي را تحت تاثير قرار مي دهد. اين مطالعه با هدف بررسي تاثير امگا 3 بر اختلالات وازوموتور در خانم هاي يايسه انجام شد. مواد و روش‎ها: پژوهش حاضر يك مطالعه از نوع كارآزمايي باليني شاهددار تصادفي شده دو سو كور بود كه بر روي 83 زن يايسه 45 تا 60 ساله، كه شرايط ورود به مطالعه را داشتند انجام شد. افراد به صورت تخصيص تصادفي در دو گروه امگا 3 و دارونما قرار گرفتند. سپس به هر دو گروه به مدت 8 هفته روزي يك عدد كپسول روغن ماهي حاوي 300 ميلي گرم امگا 3 يا دارونما تجويز گرديد. جهت گرد آوري داده‎ها از پرسشنامه اطلاعات دموگرافيك فرم هاي ثبت روزانه و پرسشنامه بسامد غذايي استفاده گرديد. نتايج با آزمون هاي آماري تي، كاي دو، من ويتني و فريدمن مورد تجزيه تحليل قرار گرفت. يافته‎ها: پس از 8 هفته مداخله، اختلاف معني‎داري بين دوگروه از نظر تعداد گرگرفتگي (003/0=p) و تعداد تعريق شبانه (001/0=p) وجود داشت. در مقايسه بين دو گروه از نظر شدت گرگرفتگي اختلاف معني‎دار ديده نشد(2/0=p) اما كاهش شدت تعريق شبانه بين دو گروه معني‎دار بود(003/0 p=). نتيجه گيري: امگا 3 بر كاهش تعداد گرگرفتگي و تعداد و شدت تعريق شبانه موثر است اما بر شدت گرگرفتگي تاثير ندارد. واژگان كليدي: گرگرفتگي، يايسگي، اسيد چرب امگا 3، علايم وازوموتور

Abstract Background: Vasomotor disorders are one of the most painful menopausal complications that negatively affect the quality of life in menopausal women. This study investigated the effects of omega3 fatty acid on vasomotor disorders in menopausal women. Materials and Methods: This randomized, double-blind, placebo-controlled clinical trial study was done on 83 menopausal women aged 45-60 years that had met the inclusion criteria. The participants were randomly assigned to omega3 or placebo groups. Fish oil capsules (containing 300 mg of omega3) or placebo capsules were prescribed to the participants one capsule a day for 8 weeks. Of the 83 patients enrolled, 68 completed the study (omega3 supplement, n=34; placebo; n=34). Data collection was done through demographic questionnaire, daily self report, and food frequency questionnaire (FFQ). Data were analyzed by t-test, Chi square, Fiedman, and Mann-Whitney tests using SPSS software version 18. Results: After 8 weeks of intervention, there was a significant difference in HF frequency (p=0.003) and nightsweats frequency (p=0.001) between the two groups. There was no significant difference in HF intensity between the two groups (p=0.2) but reduction of nightsweats intensity was significant between the two groups (p=0.003). Conclusion: Omega3 affected the reduction of HF frequency and nightsweats frequency and intensity but it did not have a significant effect on the severity of HF. Keywords: Hot flashes, Menopause, Omeg-3 fatty acids, Vasomotor symptoms Abstract Background: Vasomotor disorders are one of the most painful menopausal complications that negatively affect the quality of life in menopausal women. This study investigated the effects of omega3 fatty acid on vasomotor disorders in menopausal women. Materials and Methods: This randomized, double-blind, placebo-controlled clinical trial study was done on 83 menopausal women aged 45-60 years that had met the inclusion criteria. The participants were randomly assigned to omega3 or placebo groups. Fish oil capsules (containing 300 mg of omega3) or placebo capsules were prescribed to the participants one capsule a day for 8 weeks. Of the 83 patients enrolled, 68 completed the study (omega3 supplement, n=34; placebo; n=34). Data collection was done through demographic questionnaire, daily self report, and food frequency questionnaire (FFQ). Data were analyzed by t-test, Chi square, Fiedman, and Mann-Whitney tests using SPSS software version 18. Results: After 8 weeks of intervention, there was a significant difference in HF frequency (p=0.003) and nightsweats frequency (p=0.001) between the two groups. There was no significant difference in HF intensity between the two groups (p=0.2) but reduction of nightsweats intensity was significant between the two groups (p=0.003). Conclusion: Omega3 affected the reduction of HF frequency and nightsweats frequency and intensity but it did not have a significant effect on the severity of HF. Keywords: Hot flashes, Menopause, Omeg-3 fatty acids, Vasomotor symptoms