پديد آورندگان :
اخوان نياكي، هاله نويسنده Associate Professor, Department of Anatomy, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Akhavan Niaki, Haleh , شمالي، طيبه نويسنده Student of Pharmacy, Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Shomali, Tayebeh , آسوري، محسن نويسنده North Research Center, Pasteur Institute of Iran, Amol, Iran Asouri, Mohsen , هاشمي سوته، سيد محمدباقر نويسنده Associate Professor, Department of Immunology, Molecular and Cell Biology Research Centre, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Hashemi, Seyed MohammadBagher , حقي، حامد نويسنده علوم پزشكي مازندران Haghi, Hamed , خورشيدي، محمد نويسنده Assiastant Professor, Department of Toxicology and Pharmacology, Thalassemia Research Center and Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Science, Sari, Iran Khorshidi, Mohammad , عطايي، رامين نويسنده Lab Staff, North research center, Pasteur institute of Iran, Amol Iran Ataee, Ramin , احمدي، علي اصغر نويسنده North Research Center, Pasteur Institute of Iran, Amol, Iran Ahmadi, Ali Asghar , كاووسيان ، سعيد نويسنده Lab Staff, North research center, Pasteur institute of Iran, Amol Iran Kavosian, Saeid , امير بزرگي، گاليا نويسنده Lab Staff, North research center, Pasteur institute of Iran, Amol Iran Amirbozorgi, Galia
چكيده لاتين :
Background and purpose: Osteoporosis is a multiple disease that is characterized by decrease in bone mass and bone strength. This decrease is more common in postmenopausal women due to decreased estrogen levels. Vitamin D3 plays a pivotal role in skeletal metabolism by binding to nuclear steroid receptors (receptors for vitamin D (VDR)). This study aimed at investigating the relationship between Vitamin D3 receptor polymorphism and estrogen levels in postmenopausal women with severe osteoporosis.
Material and methods: The study population were 173 women including 91 postmenopausal women with osteoporosis and 82 women without osteoporosis (control group) aged 45-60 years of old. The study was carried out during 2011-2012. After extraction of genomic DNA from peripheral blood, FokI polymorphism (rs2228570) of the Vitamin D Receptor Gene (VDR) was investigated using polymerase chain reaction with restriction enzyme digestion (PCR-RFLP) method. Also, its relationship with bone mineral density (Bone Mineral Density) BMD, T-score, and Z-score was investigated.
Results: According to the results, there was no association between rs2228570 and osteoporosis. We observed significant differences in bone density between the two groups (P<0.001).
Conclusion: According to the findings, the association between genotype polymorphisms of vitamin D3 and osteoporosis is still unknown and other polymorphisms might affect bone density.
