مقايسه اثر دو داروي بيهوشي ارتان و مخلوط كتامين - رومپان بر ترشح اسيد پايه و تحرك شده معده ناشي از هيستامين ، كرباكول و نپتاگاسترين در رت نر

Comparison of effects of two anesthetic drugs, urethan and ketamine-rompane on basal, histamine-, carbachol-, and pentagastrin-induced gastric acid secretion in male rats

Urethan inhibits basal and histamine-stimulated gastric acid secretion (GAS). Also, ether induces similar effect on the basal and stimulated acid output. Anesthetized animals are often used in studies of regulatory mechanisms of GAS. Therefore, considering the effect of anesthetic drugs on the acid secretion is very important. The aim of this study is to compare the effects of anesthetic drugs, ketamine-rompane and urethan, on basal and stimulated gastric acid secretion. For all gastric sampling, animals were anesthetized and a polyethylene tube was introduced into the stomach through esophagus and a cannula was inserted into the pyloroduodenal junction and passed up into the stomach for saline injection and aspiration of gastric secretion, respectively. Our experiments revealed that basal acid output significantly reduced in rats given urethan compared to ketamine-rompane treated rats (P < 0.001). Also, intravenous infusion of histamine (0.5 mg/100 g/hr) and pentagastrin (2 microgram/100 g/hr) induced marked increase in acid secretion with a peak response that was started from min 30 and continued up to the end of experiments (min 90). Intravenous infusion of carbachol (1 microgram/100 g/ hr) induces marked increase in acid secretion with a peak response that was started from min 10 and continued up to min 90. In all groups, urethan compared with ketamine-rompane significantly reduced the stimulated gastric acid secretion.