اثر تخريب الكتريكي هسته هاي قاعده اي - جانبي آميگدال بر شدت تشنجهاي ناشي از كيندلينگ الكتريكي قشر پيريفورم در موشهاي صحرايي

Effect of electrical lesion of amygdala basolateral-lateral nuclei on the piriform cortex kindled seizures in rats

Amygdala and piriform cortex have critical role in temporal lobe seizures and determination of their precise role in these kinds of seizures is very important. In this study the effect of electrical lesion of amygdale basolaterallateral nuclei on the piriform cortex kindled seizures was investigated. Rats were kindled by daily electrical stimulation of piriform cortex. In the first experiment fully kindled animals received intra-amygdala 2% lidocaine (for reversal neuronal inhibition) bilaterally. Five min later, animals were stimulated and seizure parameters were measured. In second experiment, the amygdala of kindled animals was lesioned by electrical DC current bilaterally and animals were stimulated 24 h later. Daily stimulations of these animals continued for 5 days after lesion. Intra-amygdala lidocaine reduced the kindled seizures severity. There were significant increase in stage 4 latency and decrease in stage 5 duration. Amygdala lesion reduced the seizures severity more dramatically and all seizure parameters with except to seizure stage were reduced significantly. The significant reduction in seizure parameters was observed for 4 days after amygdala lesion. The basolateral-lateral amygdala neuronal activity has a critical role in propagation of epileptic seizures from piriform cortex. Elimination of this activity decreases the severity of piriform cortex kindled seizures. However, this decrease is temporally and several days later (probably because of other brain regions activation) the seizure parameters return to their control values.