بررسي تفاوت بروز سندرم ترك اعتياد در زمانهاي مختلف در موشهاي سفيد آزمايشگاهي نر و ماده در طول دوره اعتياد

Sex difference in morphine withdrawal signs during course of addiction in male and female rats

There are controversial reports about the sex differences in pain perception and morphine withdrawal signs following acute and chronic morphine administration. Therefore, the difference in withdrawal signs during time-courses of induction of morphine addiction is still of interest. In the present study the sex difference in the perception of acute, chronic and interphase pain of formalin test following chronic morphine administration for 10, 15, 20, and 26 days has been investigated. Also the severity of morphine dependence was assessed by observing withdrawal signs induced by naloxone hydrochloride in different days of addiction process. The addicted and control animals (n=8 per group) received morphine sulfate and sucrose, respectively, in their drinking water. Our results showed that acute and interphase pain was higher in female rats receiving morphine for 10, 20, 26 days, in comparison with similar treated male rats but there were not differences in chronic pain perception between two sexes. Some morphine withdrawal signs like abdominal contractions and writhing were significantly higher in female rats but other withdrawal signs including diarrhea, teeth chattering, ptosis, restlessness and weight loss were not different. It may be concluded that the acute and interphase pain of formalin test and some withdrawal signs of addicted female rats are higher than addicted male rats. This might be due to differences of central nervous system sensitivities with respect to morphine consumption in both sexes.