در موش صحرايي نر SATUREJA HORTENSIS LINN بررسي اثرات ضددردي عصاره آبي بذر گياه مرزه

There are some reports concerning the analgesic effect of the plant Safureja hortensis L. in Iranian traditional medicine. For evaluation of the possible analgesic effect of this plant, the chronic (formalin test) and acute (tail-flick) pain models were used in male rats. Administration of 62.5, 125, and 250 mg/kg (i.p.) of aqueous extract of this plant did not show any effect in the tail flick test. However, these doses of the extract produced significant analgesic effect in the first and second phases of the formalin test (p<0.001). Sodium salicylate (300 mg/kg, i.p.) only induced analgesia in the late phase of the formalin test. It can be concluded that the analgesic effect of the extract is more effective through intraperitoneal route than oral one, the analgesic effect of 250 mg/kg of the extract was more potent than 62.5 and 125 mg/kg of the extract (i.p.) and 300 and 500 mg/Kg of the extract (p.o.) and 300 mg/kg (i.p.) of sodium salicylate, and since aqueous seed extract of Safureja hortensis L. affects both phases of the formalin test, it produces its analgesic effect through central mechanisms. In addition, the analgesic effect of the extract may be attributed to its flavonoid and trepenoid content.