بررسي شيوع سرطان بعد از پيوند كليه

Incidence of Post-Renal Transplantation Malignancy

Long-term immunosuppressive therapy after renal transplantation increases the risk of developing malignancy. From 1984 to 1999, we studied 1750 renal transplant recipients at the Baghiyatollah and Labbafinejad medical centers. We found 27 cases of varying cancers. the most involved tissue was the skin (63%) and the most common type was Kaposiʹs sarcoma (n=2), followed by lymphoma (n=2), cutaneous SCC of skin (n=1), cutaneous BCC (n= 1), Melanoma (n=1), fibrosarcoma of the skin (n=1), pleuretic mesothelioma (n=1), SCC of the lung (n=1), ductal cell carcinoma of the breast (n=l), avarian cancer (n=l) and seminoma (n=1). The mean age of the patients was 44 years and the mean cancer detection time was 3 years. Eight patients died after transplantation because of rapid progression of disease and 19 patients are still alive. In our study , the most common post renal transplantation malignancy was Kaposiʹs sarcoma followed by lymphoma. It seams that in Iran, post-renal transplantation malignancy is less common than in Western countries.