) RAF( در كبد موش صحرايي DNA و واكنش آن يا AFB1 بررسي فعاليت آنزيمهاي متابوليزكننده

Activation of AFBI Metabolite Enzymes and its Reaction with DNA

Objectives: To compare aflatoxine BI effect as a carcinogen by activation and development of liver metabolite enzymes and amount of binding of aflatoxine B1 with DNA in infant rats. Materials and Methods: In this research, enzyme activation and variation after burning are exposed. Infant rat liver capability for exchanging AFB 1 to Epo-Oxide activator form and amount of binding of [3H] AFBI Epo-Oxide to DNA in "Inviter form" in the presence of variable aged liver microsoems were measured. Results: This study shows that the acieration of AFBI metabolite enzymes before adult ages is lower and a description difference is observed. Additionally, [3H] AFBI binding to DNA in infant rats are less than adult rats. Conclusion: Results of this study show that in fant rat liver has less capacity for exotoxic and exocarcinogen metabolism such as aflatoxine B1 and result in deposition and exhaustion of mentioned material in their bodies which may eventually expose them to cancer ...