يافته هاي باليني و آزمايشگاهي بيماران مبتلا به سارس در كشورهاي كانادا و هنگ كنگ

Health and Medical Aspects of Cases of SARS (Severe Acute Respiratory Syndrome) in Canada and Hong Kong

Severe acute respiratory syndrome (SARS) is a condition of unknown cause that has recently been recognized in patients in Asia (China, Singapour and Vietnam), North America and Europe. Information on the clinical features of severe acute respiratory syndrome (SARS) will be valuable to medical caring for patients who are suspected of having this disorder. In last report more than 100 cases of SARS were died. In this report summerized the initial epidemiologic findings clinical description and diagnastic finiding in 20 patients of SARS in Canada (Torento, Vancaver) and China (Hong kong) (10 patients in Canada and 10 patients in HongKong). Specimens (blood, sputum, urine) from all cases were sent to local, provincical and international laboratories for studies to identify an etiologic agent. The canadian patients were between 24 to 78 years old; who 60 percent were men and chinaes patients were 38 to 72 year old (5 men and 5 women). The most common presentation symptoms were fever and Malaise followed by nonproductive cough and dyspenea associated with infiltrates on chest radiography. Lymphopenia, elevated lactate dehydrogenase, liver aminotransferase and creatine kinase levels were available in all paitents of SARS. Empiric therapy included antibiotics, oseltamivir, corticosteroid and ribavirin. Mechanical ventilation was required in 10 patients who 5 patients died. The results of microbiologic investigations were negative. In virologic lab data especial (RT-PCR) isolated human metapneumovirus and novel coronavirus in 10 patients. SARS is a condition associated with substantial morbidity and mortality. It apears to be of viral origin, with pattern suggesting droplet or contact transmission. The role of human metapneumo virus, and novel corana virus, or both requires further investingations.