مطالعه آناتوميكي مقايسه اي رحم موش سوري معتاد به مورلين با رحم موش سالم در دوران زندگي

Comparative Anatomy of Surri Mice Addicted to Morphine and Healthy Mice

Morphine with the chemical formula C17H19No3 is the most important alkaloid of opium and is found as much as ten percent in opium and it is in two types of sulfate morphine and hydrochloride morphine. From many years ago the effect of opiate in different parts of body including fetus has been studied but a morphololigical study on the uterus of surri mouse dependent on morphine has not been carried out. In this study uterus of healthy surri Mice (Balb/c) and of Mice addicted to morphine sulfate from 3-12 weeks were studied and compared. A total number of 72 female surri mice aged 3 weeks were selected and 60 mice after being marked and weighted, were divided in to two experimental groups and 12 of them were divided in two groups of controls (water) and sham (water+sugar). Each experimental group, was given morphine orally at concentrations of 0.1 and 0.01 mg/ml in drinking water for 9 weeks respectively. The concentration of morphine was increased daily and then continued to day 63. They were again weighed and after anesthetizing, the abdominal region was incised and the uterus was studied from the viewpoint of morphology, the length and width of uterine horns and also situation of blood vessels. Between the two experimental groups, there were no significant differences from viewpoints of length and width. But between the experimental groups with 0.1 and 0.01 mg/ml of water with the sham group and control group there was a significant difference (P<0.01) and the appearance of uterus was pale and filiform. Weight changes in the control and sham groups was not significant while between control and sham with experimental groups there was a significant differnce (P<0.01). These results conclude that the morphin might change the length, width and appearance of uterus.