هيپرليپيدمي پس از پيوند كليه و ارتباط آن با بقاي پيوند و بيمار

Hyperlipidemia After Renal Transplantation And Its Relation To Graft And Patient Survival

Objectives: The aim of this study is to evaluate the incidence of hyperlipidemia alter Rʹ1ʹ. Materials and Methods: We studied 687 RT recipients in a cross-sectional design to determine the frequency of hypercholestrinemia and hypertriglycerideinia before and one month to one year after renal transplantation and its relation to patient and graft prognosis in two medical centers in Iran from 1988-2004. Cyclosporine was the constant part of immunosuppressive treatment in all study subjects. Results: One and five-year graft survival time was 94.23% and 81.34% respectively. The prevalence of hypcrcholcstrinemia after transplantation was 59.9% among patients. Mean (+2SE) serum cholesterol levels before and after transplantation were 161.15+3.81 and 213.83+4.53 mg\dl respectively, (p<0.000), and 159.99..E13.08 and 196.28+19.6 mg/dl respectively for triglyceride levels. There was no significant correlation between dose of CsA, graft and patient survival time and severity of hyperlipidemia (determined by cholesterol and triglycerid levels) in the study. Conclusions: Lipids metabolism abnormalities found in this study were similar to other studies but we could not specify a relation with patient or graft survival. In addition, there maybe a different rout for development of hyperlipidemia with adverse effect of immunosuppressive drugs in our study samples.