مطالعه سرولوژيك و باليني توكسو پلاسموز مادرزادي در كوركان شهر تهران

Congenital Toxoplasmosis in Tehran

Toxoplasmosis is an important congenital disease, which may have dangerous consequences for the fetus, following the affliction of mother during pregnancy. The affliction risk of the fetus is usually about 50%, which is closely related to the trimester when the mother is contaminated. The risk amount of contamination increases with the term of pregnancy, but at the same time, the intensity and severity of contamination is reduced. Fetus contamination varies from syndrom-free infection to very severe neurologic pathologies. Moreover, abortion may occur during the first trimester of pregnancy. In this study, 2761 samples of the blood from umblical cords (1651 samples on programmed basis and 1110 samples on random basis) of the newborns at the time of birth, as well as the blood of all the children were sampled and tested at periodic intervals, according to the research program. The motherʹs blood was tested using IFAT method, while IgM/ISAGA method was used to test the blood of umblical cords of the newborns, and finally IgM/ISAGA, IgM/IFA and TOTAL/IFA methods were used to test the toxoplasmic children. The results show that from 18 cases of pregnancy contaminated with the parasite, one case ended to abortion, and eight cases caused fetus contamination. From the samples of umblical cords which were collected randomly, four cases were reported to be positive from the viewpoint of toxoplasmosis antibody. One infant died and the other three were contaminated. The Newborns contamination varies from subclinical congenital toxoplasmosis to cases with complications such as retinochoroidities, purpura, convulsions, diplopia, mental retardation, etc.