B نقش فتوتيپهاي آلفا يك آنتي تريپسين در بيماران مزمن كبدي مبتلا به هپاتيت

The Role of Alpha 1 Antitrypsin Phenotypes in HBV Patients

Alpha 1 antitrypsin (AAT) is the most abundant protease inhibitor in human plasma. It has a central function as a protective protein in controlling tissue degredation by inhibiting a large number of proteases. The deficiency state caused more than 90 alleles which differ by point mutation. One subgroup of these mutations is associated with the development of chronic liver disease, leading to cirrhosis and hepatoma. However, unlike pulmonary disease, the role of a low peripheral AAT value has not been clearly established in the pathophysiology of chronic liver disease. 122 HBV patients and 100 normal individuals who referred to the Tehran Hepatitis Center and Zahedan Hepaptitis Clinic have entered the study. The AAT phenotype in HBV groups are as follows: 98 individuals with normal phenotypes (M,M„M,M2 and MZM2) and 24 had moderate deficient phenmotypes (MS, MZ, MV, M,Z). The AAT phenotypes in normal groups are as follows: 95 individuals with normal phenotyps (M,M„M,M2and MZM2), and 5 individuals with deficient and moderately deficient phenotypes (MS, MZ, MV, M,S, M,Z). Therefore there is a significant difference between HBV and the normal population in AAT phenotypes (p<0.005). Our results support the view that the risk for HBV infection might be increased in individuals with moderately deficient or deficient AAT phenotypes. But for better results larger population of study might be needed.