كليدواژه :
سولفورموستارد , فيبروز ريه , سيتوكين , Sulfur Mustard , INF , Pulmonary Fibrosis , ضايعات مزمن ريه , Cytokine INF-Gama Chronic Pulmonary Lesions , داروي گامااينترفرون , پزشكي
چكيده لاتين :
In Iran-Iraq war many thousands of Iranian soldiers exposed to mustard gas which lead to chronic pulmonary diseases such as chronic bronchitis, bronchiolitis, bronchiectasis, stenosis in main brochi and trachea or pulmonary fibrosis. Attempts for treating in this patients only reduced complications and pulmonary infections. Corticosteroides and immunosupressive agents are prescripted mainly, but they can not suppress improvement of the lesions and patients still suffer from pulmonary fibrosis and chronic lesions (u,s). TH1 and TH2 cytokines have an opposite regulatory effects and the balnce among them plays a central role on the immuneresponse regulation. Lung tissue and blood studies in patients with LF have revealed an absolute and relative deficit of IFN-Gama as compared with TH2 cytokines in the lungs, which ends in the increasing number of fibroblasts, increased levels of transforming Beta growth factor (TGF (3) and an accumulation of collagen. Normally the TH1 cytokine gamma (interferon (IFN-y)) counters fibroproliferation by downregulating the gene that responsible for transcription of TGF fl. In this study two groups of chemical victims with were randomised. One of the groups treated by standard treatment and the other treated with 200 yg Gammainterferon 3 times a weak and 7.5 mg prednisolon orally. For 12 months clinical signs (Dyspnea Index, Hospitalization, 02 need) pulmonary function tests, HRCT, ABG studied on baseline and at 1,3,6,12 months were checked. For Adverse reaction of drug kidney function (Bun, cr), liver function (SGOT SGPT, CPK, BIL), CBC, Platlet counts were considered. clinical signs had a dominant difference (dyspnea index hospitalization. 02 need)in case group. Compared with control group, in pulmorary function (PFT) significant statistical forced vital capacity was seen. (P<0.001), also significant rise in pao2 in patients recieved Gamma-interferon was detected.
