بررسي ميزان فراواني اختلالات متابوليسم گلوكز در بيماران بتاتالاسمي ماژور بالاي 10 سال بيمارستان هاجر(س ) شهر كرد در سال 1382

Prevalence of glucose metabolism disorder among over 10 years old thalassemic patients, Hajar hospital of Shahrekord, 2003

Background and aim: Hypertransfusion therapy has increased the duration and quality of life in the patients with 13 thalassemia major. However it could lead to chronic iron overload and viral hepatitis that induce complications such as glucose metabolism disorders. The aim of this study was to find the prevalence of glucose metabolism disorders among (3-thalassemic patients and compare with matched normal control group. Methods: The case group consisted of 40 multitransfused thalassemic patients (10-20 years old, FIM=47.5%,52.5%) and the control group consisted of 40 matched normal persons. OGTT (Oral Glucose tolerance Test: blood sugar response to oral load of 1.75 gl kg glucose) was performed in all persons. We also determined desferal dosage, serum ferritin level and markers of viral hepatitis (including HbsAg-HCV Ab-SGOT, SGPT, ALK.P) in thalassemic patients . Results: The prevalence of glucose metabolism disorders was higher in the thalassemic patients compared to the normal group (15% versus 0%,P=0.01). Glucose metabolism disorders was not higher in patients with thalassemia and viral hepatitis than thalassemic patients without hepatitis (16.6% versus 8.8%,P>0.05). The high frequency of glucose metabolism disorders in thalassemic patients was related to serum ferritin level (P<0.05). Conclusion: Our data showed the role of iron overload in glucose metabolism disorders and requirement of periodic control of serum ferritin level in p-thalassemia major patients.