تاثير اسيد اسكوربيك بر هيپرليپيدمي

Effect of Scorbic acid on Hyperlipidemia

Hyperlipidemia is one of the most important risk factors for atherosclerosis, which in tern is a basic factor in development of infarction and other heart diseases. Although there are useful drugs to reduce hyperlipidemia, but more effective drugs, with less side effects are yet necessary. It has been claimed that vitamin C might be effective in reducing hyperlipidemia. Therefore, the aim of this study was to examine the effect of this vitamin on blood triglycerides, cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL), in patients using lovastatin. In a double blind, clinical study, 62 hyperlipidemic patients, designated into two groups, equally. After a blood test for lipids, group one received 1000mg vitamin C and group two placebo. Both groups were using lovastatin for their hyperlipidemia. After 10 weeks their blood were checked for cholesterol, triglyceride, LDL and HDL and compared with these parameters before vitamin C usage. None of these parameters changed except, HDL. The HDL of patients using vitamin C increased compared with placebo group, or with the HDL before vitamin C usage (P<0.05). Therefore, although vitamin C cannot reduce cholesterol, triglyceride or LDL, however, adding it to hyper lipid regimen, seems to be useful, due to increasing HDL in patients.