بررسي تاثير تزريق مخلوط آتروپين - پرومتازين بر طول مدت مراحل زايماني و آپگار نوزاد

The effect of atropine and promethazine on the labor process and apgar score of infants

Since in most labor departments a mixture of atropine and promethazine is used to decrease the labor period, but its effect is still controversial, this randomized clinical trial was performed to assess the effects of this drug mixture on the progress of labor and apgar of infants. 200 pregnant women were randomly assigned to two groups (case and control). The case group received 0.5mg atropine and 25mg promethazine. The control group received 2ml of sterile water. These drugs were injected once at the beginning of the active phase of labor. Labor progress and first apgar score were recorded. The mean labor progression of the case and control groups in nuliparous women was 253.29 and 231.41 minutes respectively, which didnʹt indicate a significant statistical difference. These times in multiparous women were 232.67 and 199.04 minutes. The mean of the second stage of labor was 42.58 and 35.32 minutes in nulliparous women and 11.53 and 11.22 minutes in multiparous women that didnʹt indicate a significant difference. The mean of the first apgar score was not significant between two groups in nulliparous and multiparous women. These findings indicated that atropine and promethazine had no positive impact on the progression of the labor and was considered to be a waste of time and medicine.