رابطه آنتي ژن هاي كلوسيتي انسان با آسم آلرژيك

The evaluation of HLA class I associaiton with allergic asthma

Major histocompatibility complex (MHC), which plays a major biological function in immune response, is generally associated with so many human diseases. During recent years a new clinical relevance of MHC diseases. On the other hand there is a strong correlation between some autoimmune diseases and MHC system such as in some alergic abnormalities and its relation with HLA antigens. In order to investigate this concept 30 atypic asthmatic patients and 100 healthy controls were selected. Human leukocyte antigen (HLA) typing was performed by standard N.I.H procedures and the results analysed. The frequency of HLA-A2, A11, Aw19 and HLA-B5 1 decreased in atypic asthmatic patients while no assocation recorded significantly between HLA-C and allergic asthma. The results of our study indicated that there was a significant relationship between allergic asthma and HLA-I antigens.