در 03 بيمار مبتلا به سرطان پستان فاميلي BRCA1 رديابي جهش در اگزون هاي 3، 01 و 21 ژن

Breast cancer is one of the most common cause of death due to cancer in women. More than half of hereditary breast / ovarian cancer families could be attributed to mutation in breast cancer susceptibility gene BRCAI. This study was performed on blood samples 4 30 women who affected with familial breast cancer. Non-radioactive PCR-SSCP technique was utilized for mutation screening in exons 3, 10, 12 of BRCAI gene. Two shifts in exon3 and also two in exon 12 was detected, but no shift in exonlO was found. Due to low number of recognized mutations, the statistical analysis didnʹt show a meaningful correlation between mutations and pathological characteristics. Results from this study showed that there was a low possiblity of germline mutation in these three exons. Low rate of mutation in this report was concordance with the others.