تغييرات سطح سرمي روي و مس قبل و بعد از عمل دياليز در شهر گرگان

Serum zinc and copper variation before and after heamodialysis in Gorgan

Background and Objectives: Zinc and copper are the important trace elements for human growth and bodyʹs biological functions. These trace elements are the important Cofactors of many enzymes. Serum variation of these trace elements are clinicaly important and should be taken into consideration, because fluctuation of these elements are behind many clinical manefestation in human. Diarahea and vomiting can be the clinical symptoms associated with the toxic level of zinc and copper in the body. The concept behind this study is to determine the serum levels of zinc and copper in haemodialysis patients before and after dialysis, to explain the differences of such trace element concenteration in these patients. Materials and Methods: This project is a comparative study. The sample population was 50 of haemodialysis patients choosen randomly from the patients reffered to the 5th Azar hospital in Gorgan (33 male and 17 female). The concenteration of Zinc and Copper of these patients was determined before and after the dialysis. Results: The results from this research projects indicate that the average concenteration of zinc and copper in haemodialysis patients after dialysis were 135.32±59.32 and 136.40 ±51.25 microgram/deci litre which markedly increase in compare to the serum concenteration of these trace elements before the dialysis which were 78.38±37.46 and 89.92±32.54 microgram/deci litre respectively. On the basis of the results, we found in this study the average increased concenteration of zinc and copper after the process of dialysis among the haemodialysis patients had a meaningful statistical variation (P<0.00 l ). Conclusion: Uremia, dialysis blood tube, heavy metal contamination, the quality of dialysis membrane and the quality of water used for the process of dialysis can be a reason for the increased concenteration of zinc and copper. Such increase in the serum concenteration ofʹ these trace elements can be the basis for some clinical abnormalities. Therefore it is suggested to determine the rate of released zinc and copper from haemodialysis machine, before the procedure is done; to enable the medical team to evaluate the serum zinc and copper and correct it by nutritional therapy.