عنوان مقاله :
Anti-ulcerogenic activity of stem extract and fractions of Homalium letestui
پديد آورندگان :
Louis U, Amazu Department of Pharmacology and Therapeutics - College of Medicine - Evans Enwerem University - Orlu Campus, Imo State , Jude E, Okokon Department of Pharmacology and Toxicology - Faculty of Pharmacy - University of Uyo, Uyo, Nigeria , Lucky L, Nwidu Department of Pharmacology and Toxicology - Faculty of Pharmacy - Niger Delta University - Wilberforce Island, Bayelsa State
كليدواژه :
Homalium letestui , Gastric protective , Antiulcer
چكيده لاتين :
Background & Aim: Homalium letestui Pellegr (Flacourtiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties. Experimental: The effects of ethanol stem extract of H. letestui (200 – 600 mg/kg) and fractions (Aqueous and Dichloromethane, 400 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin, reserpine and histamine –induced ulcer models.
Results & Discussion: The extract (200 – 600 mg/kg) inhibited ethanol, indomethacin, reserpine and histamine –induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001). The effects of the extract/fraction were comparable to that of the standard drugs used in indomethacin and ethanol-induced ulcer models with the dichloromethane fraction having the highest activity. Industrial and practical recommendations: The present study demonstrates that stem extract of Homalium letestui might to be useful for the treatment of ulcer.
عنوان نشريه :
داروهاي گياهي
عنوان نشريه :
داروهاي گياهي