پديد آورندگان :
Jude E, Okokon Department of pharmacology and toxicology - Faculty of pharmacy - University of Uyo, Uyo, Nigeria , Koofreh, Davies Department of physiology - Faculty of basic medical sciences - University of Uyo, Uyo, Nigeria , Bassey S, Antia Department of chemistry - University of Uyo, Uyo, Nigeria
كليدواژه :
Zea mays , Anti-inflammatory , Analgesic , GC-MS
چكيده لاتين :
Background & Aim: Zea mays leaf used traditionally in Ibibio ethno medicine in Southern Nigeria to treat malaria and other inflammatory diseases. These anti-inflammatory and analgesic properties were evaluated against experimentally induced inflammation and pains using standard models. Experimental: The effects of ethanol leaf extract of Zea mays (170 -510 mg/kg) on experimentally induced inflammation and pain were studied in rats using Carrageenin, egg albumin and xylene-induced inflammation as well as acetic acid-induced writhing and thermal induced pain models. The GCMS analysis of the most active fraction was carried out. Results: The extract (170 -520 mg/kg) inhibited inflammation and pains caused by different phlogistic agents used in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001), though incomparable to that of the standard drugs used (ASA and indomethacin). The GC-MS revealed the present of polyunsaturated fatty acids and phenolic compounds which may be responsible for the observed activities of the extract.
Recommended applications/industries: The present study demonstrates that leaf extract of Zea mays might to be useful for the treatment of inflammation and pains.
