Title of article :
Effects of low-temperature surface-wave plasma treatment with various gases on surface modification of chitosan
Author/Authors :
Akihisa Ogino، نويسنده , , Martin Kral، نويسنده , , Mitsuji Yamashita، نويسنده , , Masaaki Nagatsu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The effect of low-temperature surface-wave plasma treatment with various gases on surface modification of chitosan was investigated using the surface-wave plasma. Chitosan is a nontoxic, biocompatible and biodegradable polymer. It is thought that an increase in amino groups, a key constituent of chitosan molecules, will be useful for biomedical applications, such as improvement of blood clotting properties, drug delivery system, prodrug using derivatization and so on. In this study, therefore, we have focused on the amino group introduction on chitosan surface by using Ar, O2, NH3 and NH3–He mixed gas plasmas.
The experimental results of X-ray photoelectron spectroscopy measurements showed that N/C atomic ratio increased from 6.8% to 14.7% after NH3 plasma treatment. With O2 plasma treatment, the surface roughness of chitosan film was significantly modified from 1.96 nm to 14.6 nm. The blood clotting time of the sample treated by NH3 and He plasma with O2 pretreatment was reduced to 55.2% of that of untreated one.
Keywords :
Surface-wave plasma , Surface modification , Chitosan , Blood clotting , Amino group introduction
Journal title :
Applied Surface Science
Journal title :
Applied Surface Science