Author/Authors :
Teunis B.H. Geijtenbeek، نويسنده , , Douglas S Kwon، نويسنده , , Ruurd Torensma، نويسنده , , Sandra J. van Vliet، نويسنده , , Gerard C.F van Duijnhoven، نويسنده , , Jeena Middel، نويسنده , , Ine L.M.H.A Cornelissen، نويسنده , , Hans S.L.M Nottet، نويسنده , , Vineet N KewalRamani، نويسنده , , Dan R Littman، نويسنده , , Carl G. Figdor، نويسنده , , Yvette van Kooyk، نويسنده ,
Abstract :
Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.
