Title of article :
Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites
Author/Authors :
John L. Goodier، نويسنده , , Haig H. Kazazian Jr.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Pages :
13
From page :
23
To page :
35
Abstract :
Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up roughly 40% of the mammalian genome and have played an important role in genome evolution. Their prevalence in genomes reflects a delicate balance between their further expansion and the restraint imposed by the host. In any human genome only a small number of LINE1s (L1s) are active, moving their own and SINE sequences into new genomic locations and occasionally causing disease. Recent insights and new technologies promise answers to fundamental questions about the biology of transposable elements.
Journal title :
CELL
Serial Year :
2008
Journal title :
CELL
Record number :
1019432
Link To Document :
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