Title of article
DNA Repair, Genome Stability, and Aging
Author/Authors
Lombard، David B. نويسنده , , Chua، Katrin F. نويسنده , , Mostoslavsky، Raul نويسنده , , Franco، Sonia نويسنده , , Gostissa، Monica نويسنده , , Alt، Frederick W. نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
-496
From page
497
To page
0
Abstract
Aging can be defined as progressive functional decline and increasing mortality over time. Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates with age, and DNA repair defects can cause phenotypes resembling premature aging. We discuss how cellular DNA damage responses may contribute to manifestations of aging. We review Sir2, a factor linking genomic stability, metabolism, and aging. We conclude with a general discussion of the role of mutant mice in aging research and avenues for future investigation.
Keywords
DIGLYPHUS ISAEA , Liriomyza trifolii , Abamectin compatibility , Biological control , IPM , Greenhouse
Journal title
CELL
Serial Year
2005
Journal title
CELL
Record number
102161
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