Title of article
Tumor Necrosis Factor: An Apoptosis JuNKie?
Author/Authors
Ashkenazi، Avi نويسنده , , Varfolomeev، Eugene E. نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
-490
From page
491
To page
0
Abstract
TNFʹs main function is to stimulate inflammation by turning on gene transcription through the IKK/NF(kappa)B and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF.
Keywords
Emissions , NOx storage/reduction catalysts , NOx storage , NOx release , Catalyst , NO oxidation
Journal title
CELL
Serial Year
2004
Journal title
CELL
Record number
102461
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