Author/Authors :
Alexey Bulychev، نويسنده , , John R. Bellettini، نويسنده , , Michael OʹBrien، نويسنده , , Peter J. Crocker، نويسنده , , Jean-Pierre Samama، نويسنده , , Marvin J. Miller، نويسنده , , Shahriar Mobashery، نويسنده ,
Abstract :
Structure-function analysis with a series of N-sulfonyloxy β-lactam molecules as inhibitors of β-lactamases is reported. The best of these compounds acylate the active site of the class A TEM-1 β-lactamase from Escherichia coli rapidly, and resist deacylation. Whereas acylation of the active site of the class C β-lactamase from Enterobacter cloacae was not seen, these compounds function as competitive inhibitors of this enzyme.
