Title of article :
A novel entry into a new class of spiroheterocyclic framework: regioselective synthesis of dispiro[oxindole-cyclohexanone]pyrrolidines and dispiro[oxindole-hexahydroindazole]pyrrolidines
Author/Authors :
M. Amal Raj، نويسنده , , R Raghunathan، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
2,6-Bis(arylmethylidene)cyclohexanones undergo a regioselective 1,3-dipolar cycloaddition reaction with the azomethine ylide derived from isatin and sarcosine by a decarboxylative route affording a series of 1-N-methyl-spiro[2.31]oxindole-spiro[3.211]611-arylmethylidenecyclohexanone-4-aryl-pyrrolidines which were further annulated to give a series of novel 1-N-methyl-spiro[2.31]oxindole-spiro[3.711](311-aryl)Δ111,711a-hexahydro-2H-indazole-4-aryl-pyrrolidines. The structures of which were established by spectroscopic techniques as well as single crystal X-ray analysis.
Keywords :
3-dipolar cycloaddition , 1 , 6-bis(arylmethylidene)cyclohexanones , decarboxylative route , Sarcosine , Isatin , dispiropyrrolidines , 2
Journal title :
Tetrahedron
Journal title :
Tetrahedron