Synthesis of two stereoisomeric polydentate ligands, trans and cis cyclopentane-1,2-diaminotetraacetic acids, and complexation by 111In and 153Sm

Two polyaminocarboxylic acid chelating agents were synthesized. Complexation properties regarding 111In and 153Sm, two radionuclides suitable for applications in immunoscintigraphy and radioimmunotherapy were investigated. The synthesis of aminodiacetic acid derivatives and involved preliminary stereoselective synthesis of the corresponding amines, cis and trans cyclopentane-1,2-diamines. 111In labelling confirmed the complexation abilities of the two ligands. An additional comparative study to probe the relationship between ligand structure and metal complex was performed with 153Sm.